By Gerardo R. Vasta PhD, Hafiz Ahmed PhD

Introduces Groundbreaking ways for Assessing Lectin Function

Lectins and their ligands are lower than really a heavy microscope because of their strength functions to pharmacology, immunology, melanoma remedy, and agriculture. With turning out to be curiosity within the glycobiology box, the physique of analysis relating to lectin roles has grown at an explosive expense, really some time past twenty years. Animal Lectins: A useful View provides the main updated research of those carbohydrate-binding, and in all probability lifesaving, proteins in a single finished quantity.

This standard-setting source provides new insights into the organic roles of so much animal lectins, together with their functionality in an infection prevention via innate immunity. It additionally discusses such lectin behaviors as:

  • Glycoprotein folding
  • Sorting and targeting
  • Cell adhesion
  • Embryogenesis
  • Cell-cell interactions and signaling

Describes the Structural foundation of Protein-Carbohydrate Interactions

Under the editorial counsel of 2 top protein chemistry specialists and with contributions from well-recognized box gurus, this booklet logically and systematically discusses either intracellular and extracellular lectin capabilities. it's a necessary springboard for destiny box study and a transparent and concise wisdom base that glycobiology, biochemistry, and immunology researchers can't have the funds for to be without.

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2. L. 1899 Recherches experimentales sur une agglutinine produite par la glande de l’albumen chez l’Helix pomatia. R. Acad. Sci. 129, 233. 3. M. and Robin, C. 1853 Observation de leocythemie. C. R. Mem. Soc. Biol. 5, 44–50. 4. Leyden, E. 1872 Zur Kenntniss des bronchial-asthma. Arch. Pathol. Anat. 54, 324–344. 5. R. 8 A° resolution. Biochemistry 38, 13837–13843. 6. Flexner, S. and Noguchi, H. 1902 Snake venom in relation to haemolysis, bacteriolysis, and toxicity. J. Exp. Med. 6, 277–301. 7. C.

Furthermore, some unique structural features can be identified in the most divergent family members. , 1999). , 1999). , 2004). , 1998; Saussez and Kiss, 2006). 2) of galectin-7 shows that dimerization of this lectin is very different from those of dimeric galectins. , 1998; Rini and Lobsanov, 1999). 3 CARBOHYDRATE-BINDING SPECIFICITY OF GALECTINS THEIR CARBOHYDRATE-BINDING SITES AND The ability of galectins to discriminate among carbohydrate structures is striking. , 1990, 1996, 2004). For most galectins, LacNAc and thiodigalactoside (TDG) are 5–10 times more active than Lac.

1974 The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins. J. Biol. Chem. 249, 5536–5543. 15. , and Resheff, G. 1975 A β-Dgalactoside binding protein from electric organ tissue of Electrophorus electricus. Proc. Natl Acad. Sci. USA 72, 1383–1387. 16. I. J. 1965 Specific binding of concanvalin A to cross-linked dextran gels. Biochem. J. 96, 23C–25C. 17. M. 2001 The ABO blood group system: Historical background. Transfus. Med. 11, 243–265. 18. Kocourek, J.

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